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            首頁   >>   技術文章   >>   科研賦能:SP-ICP-MS與SC-ICP-MS技術的煥新升級之旅

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            科研賦能:SP-ICP-MS與SC-ICP-MS技術的煥新升級之旅

            閱讀:509      發(fā)布時間:2024-4-11
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            ICP-MS是目前應用較廣泛的原子光譜技術之一, PerkinElmer積極倡導的Single Particle單顆粒(SP)ICP-MS和Single Cell單細胞(SC)ICP-MS技術,隨著前處理和實驗技術、ICP-MS儀器及其數(shù)據(jù)處理軟件的不斷發(fā)展,正越來越多受到環(huán)境、食品、藥物、醫(yī)學、材料和工業(yè)等領域的關注和使用,幫助高校、科研機構和政府實驗室老師研究納米顆粒、微納塑料、細胞、微生物等微粒子,助力老師們不斷探索和創(chuàng)新。


            SP-ICP-MS工作原理

            SP-ICP-MS的工作原理是將分散在溶液中的納米顆粒物引入ICP-MS的離子源,單個納米顆粒在高溫等離子體中瞬時形成一束含特定元素的離子流,通過四極桿質量分析器的掃描分離,在檢測器中產(chǎn)生特征元素的脈沖信號峰,根據(jù)脈沖信號峰個數(shù)與粒子數(shù)量、脈沖峰強度與粒子粒徑的正相關關系,獲得目標顆粒物的數(shù)量、粒徑等信息。它能同時獲得納米顆粒濃度與粒徑分布、團聚信息,能快速定量粒子內(nèi)外特定元素含量,具有靈敏度高、選擇性強等優(yōu)點,是一項新興納米顆粒定性和定量的檢測方法。

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            SP-ICP-MS分析技術的核心是需要ICP-MS具有快速時間分辨能力。PerkinElmer NexION系列ICP-MS,最快瞬時采集速率達100 000點每秒,可直接表征小粒徑、多成分或多形狀的納米材料,如10nm Au NPs數(shù)量和粒徑測定、金納米棒的長短分析[1]、Au-Ag核-殼型納米顆粒在光照和外界環(huán)境中的轉變表征[2]、無需消解直接快速測量上千根單壁碳納米管中殘留金屬釔(常用催化劑)[3]、半導體有機溶劑中超痕量雜質顆粒物[4]等;在環(huán)境研究方面,SP-ICP-MS可用于定量評價NPs在河流中的溶解動力學[5]、CeO2 NPs在土壤基質中的變化[6]、通過測定碳13同位素篩選測定微塑料[7]等;在食品、農(nóng)作物毒理研究方面,SP-ICP-MS可測定海養(yǎng)殖的雙殼類軟體動物中金屬基納米顆粒[8]、探索納米氧化鈰暴露對大豆植物生長影響[9]等;在生命科學方面,SP-ICP-MS可評價海藻中TiO2 NPs的累積程度[10]、CuO NPs對土壤微生物群落的生態(tài)毒理效應[11];而在醫(yī)學領域,SP-ICP-MS可量化NPs的暴露水平并做風險評估,如追蹤生物體液中金屬基NPs的行為[12],同時可作為標記物判斷疾病,如與磁免疫測定法結合測定肺癌中腫瘤生物標志物[13]等。

             

             

            以單個細胞為單位,發(fā)現(xiàn)細胞個體間的差異對于闡釋相關金屬在細胞內(nèi)的遷移轉化及其毒理也十分重要,基于SP-ICP-MS技術的單細胞SC-ICP-MS技術,將含特定元素的細胞視為一個整體,通過單細胞專用進樣系統(tǒng)引入檢測,實現(xiàn)含特定元素細胞的數(shù)量及單個細胞中元素含量測定。SC-ICP-MS能監(jiān)測含特定金屬元素的細胞個數(shù),測定細胞中金屬含量,有效評估細胞個體差異,能作為細胞特異性識別工具。在生命科學方面, SC-ICP-MS可監(jiān)控藻類細胞對NPs和金屬離子攝入行為[14]、可對金屬元素標記的單細菌細胞進行識別和計數(shù)[15]等;在醫(yī)藥學研究領域,SC-ICP-MS既能量化細胞中金屬含量,如SC-ICP-MS同時計數(shù)含Cu人血紅細胞及其Cu含量[16],又能給無機元素相關藥物開發(fā)與給藥提供指導意見,如通過SC-ICP-MS測定抗癌藥物單核Ir和雙核Ir(III)化合物在單個癌細胞的攝入和排出情況,首次量化證實雙核Ir(III)化合物的光催化抗癌效果更好[17]等。

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            △Asperon™ 單細胞進樣

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            △單細胞ICP-MS分析

             

             


            SP-ICP-MS和SC-ICP-MS技術作為ICP-MS的前沿應用之一,本文對基本原理及在多學科的典型應用做了概述,若想了解詳細內(nèi)容,掃描下方二維碼獲取《PerkinElmer 單顆粒/單細胞ICP-MS應用合集》。

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            ?參考文獻

            參考文獻

             

            [1]Dimensional characterization of gold nanorods by combining millisecond and microsecond temporal resolution single particle ICP-MS measurements. G´abor Galb´acs. Department of Inorganic and Analytical Chemistry, University of Szeged, D´om square7, 6720 Szeged, Hungary. Journal of Analytical Atomic Spectrometry 2017

            [2]Transformations of Gold-Silver Core-shell Nanoparticles in Exposure Media Measured by SP-ICP-MS. Ruth Merrifield,Jamie Lead,Center for Environmental NanoScience and Risk (CENR),Arnold School of Public Health,University of South Carolina,Chady Stephan,PerkinElmer, Inc. PerkinElmer Application Note 2016

            [3] Analysis of Single-Walled Carbon Nanotubes with SP-ICP-MS. Jingjing Wang,James F. Ranville,Department of Chemistry and Geochemistry,Colorado School of Mines,Golden, CO. PerkinElmer Application Note 2017

            [4] Analysis of Iron Nanoparticles in Organic Solvents Used in the Semiconductor Industry Using Single Particle ICP-MS in Reaction Mode. Chady Stephan,PerkinElmer, Inc. Shelton, CT. PerkinElmer Application Note 2022

            [5] Quantitative Evaluation of Nanoparticle Dissolution Kinetics using Single Particle ICP-MS: A Case Study with Silver Nanoparticles.Denise Mitrano James F. Ranville Department of Chemistry and Geochemist ry Colorado School of Mines Golden, CO USA Chady Stephan PerkinElmer, Inc. Shelton, CT. PerkinElmer Application Note 2014

            [6] A Sensitive Single Particle- ICP-MS Method for CeO2 Nanoparticles Analysis in Soil during Aging Process. Honglan Shi.Missouri University of Science and Technology, Chemical Department, Energy and Environment Research Center, J. Agric. Food Chem 2021

            [7] Unlocking Carbon-13 with Single Particle ICP-MS: Feasibility Study for Microplastic Detection.Francisco Laborda Celia Trujillo University of Zaragoza Zaragoza, Spain Ryszard Lobinski Université de Pau et des Pays de L’Adour Pau, France. PerkinElmer Application Note 2022

            [8] Ultrasound assisted enzymatic hydrolysis for isolating titanium dioxide nanoparticles from bivalve mollusk before SP-ICP-MS. A.Moreda-Pineiro. Chemistry School of Santiago de Compostela University in Spain. Analytica Chimica Acta 2018

            [9] Effect of nano cerium oxide on soybean(Glycine max L. MERRILL)crop exposed to environmentally relevant concentrations. Hudson W. P. de Carvalho, School of Engineering, University of Guelph. Thornbrough Building, 50 Stone Rd E, Guelph,Ontario, N1G 2W1, Canada. ChemoSphere 2020

            [10] Titanium dioxide nanoparticles assessment in seaweeds by single particle inductively coupled plasma-Mass Spectrometry.Antonio Moreda-Pi˜neiro.Chemistry Department, Santiago de Compostela University, Spain. Talanta 2021

            [11] Ecotoxicological effects of copper oxide nanoparticles (nCuO) on the soil microbial community in a bisoids-amended soil. Ajith Dias Samarajeewa,Soil Microbial Assessment and Genomics Laboratory, Biological Assessment and Standardization Section, Environment and Climate Change Canada. Science of the Total Environment 2020

            [12] Assessing the Fate of Nanoparticles in Biological Fluids using SP-ICP-MS.Ciprian-Mihai Cirtiu Normand Fleury National Public Health Institute of Quebec (INSPQ), Canada Chady Stephan PerkinElmer, Inc. Shelton, CT. PerkinElmer Application Note 2017

            [13] Detection of three tumor biomarkers in human lung cancer serum using single particle inductively coupled plasma mass SPectrometry combined with magnetic immunoassay. Biyang Deng. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. Spectrochimica Acta Part B 2020

            [14] Monitoring the Uptake of Nanoparticles and Ionic/ Dissolved Gold by Fresh Water Algae using Single Cell ICP-MS. Ruth Merri ed1 Jamie Lead1 Chady Stephan2 1 Center for Environmental NanoScience and Risk (CENR), Arnold School of Public Health University of South Carolina, SC 2PerkinElmer Inc. Shelton, CT. PerkinElmer Application Note 2018

            [15] Counting and recognizing single bacterial cells by a lanthanide encoding inductively coupled plasma mass SPectrometric approach. 王秋泉,廈門大學 化學系. Anal. Chem 2019

            [16] A highly efficient introduction system for single cell- ICP-MS and its application to detection of copper in single human red blood cells. Biyang Deng,廣西師范大學 化學與藥物科學學院. Talanta 2019

            [17] Single-Cell Quantification of a Highly Biocompatible Dinuclear Iridium(III)Complex for Photocatalytic Cancer Therapy.黃懷義,中山大學藥學院(深圳). Angewandte Chemie 2022

             

             

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