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神經(jīng)科學(xué)熱門產(chǎn)品6：鉀離子通道Blockers
閱讀：1427 發(fā)布時間：2022-8-2
鉀離子通道阻斷劑（Potassium Channel Blockers），是一類可抑制K+通過膜通道的化合物，包括有機(jī)化合物和各類神經(jīng)毒素（如α-Dendrotoxin，Apamin 等）
鉀離子通道是四聚體的整合膜蛋白，形成水孔，K+可以通過水孔流動，并在許多生物體中發(fā)現(xiàn)。在神經(jīng)元中，K+通道參與維持靜息電位、動作電位后的膜復(fù)極、控制重復(fù)放電的時間。K+通道是生物體內(nèi)廣泛的離子轉(zhuǎn)運(yùn)分子，在人類體內(nèi)有70多個基因編碼不同的K+通道。
下表給大家?guī)砣N針對不同鉀離子通道的阻滯劑（Blocker）：電壓門控鉀離子通道抗體（Voltage-gated Ion Channel，簡稱Kv）、鈣激活鉀離子通道（Ca2+-Activated K+ Channels，簡稱KCa）、 內(nèi)向整流型鉀離子通道（Inward Rectifier K+ Channels，簡稱Kir）
電壓門控離子通道Blocker
| 靶點(diǎn)通道 | 品名 | 貨號 | 來源 |
| Various KV 離子通道 | ShK (Stichodactyla Toxin) | STS-400 | Synthetic peptide |
| Various KV 離子通道 | Stromatoxin-1 | STS-350 | Synthetic peptide |
| Various KV 離子通道 | Guangxitoxin-1E | STG-200 | Synthetic peptide |
| Various KV 離子通道 | 4-Aminopyridine | A-115 | Synthetic |
| A-type and Shaker-related | Pandinotoxin Kα | STP-500 | Synthetic peptide |
| Kv1.1, Kv1.2, Kv1.6 | α-Dendrotoxin | D-350 | Natural peptide |
| Kv1.1, Kv1.2 | β-Dendrotoxin | D-360 | Natural peptide |
| KV1.1, KV1.6，Kir1.1 | δ-Dendrotoxin | D-380 | Natural peptide |
| KV1.1, KV1.2 | γ-Dendrotoxin | D-370 | Natural peptide |
| KV1.1, KV1.2 | Dendrotoxin-K | D-400 | Natural peptide |
| KV1.1, KV1.2 | Dendrotoxin-I | D-390 | Natural peptide |
| KV1.1, KV1.2, KV1.3 | Hemitoxin | STH-500 | Synthetic peptide |
| KV1.1, KV1.2, KV1.3 | Hongotoxin-1 | RTH-400 | Recombinant, E. coli |
| KV1.1, KV1.2 | MCD peptide | STM-250 | Synthetic peptide |
| KV1.1, KV1.2, KV1.3, KCa3.1 | OsK-1 | RTO-150 | Recombinant, E. coli |
| KV1.2, KV1.3，KCa1.1 | Charybdotoxin | STC-325 | Synthetic peptide |
| KV1.2 | κ-Conotoxin RIIIJ | STC-660 | Synthetic peptide |
| KV1.2 | κ-Conotoxin RIIIK | STC-650 | Synthetic peptide |
| KV1.2 | Tityustoxin-Kα | STT-360 | Synthetic peptide |
| KV1.2, KV1.3 | Noxiustoxin | STN-340 | Synthetic peptide |
| KV1.3 | Aa1 Toxin | RTA-400 | Recombinant, E. coli |
| KV1.3 | ADWX-1 | STW-100 | Synthetic peptide |
| KV1.3 | Agitoxin-1 | RTA-150 | Recombinant, E. coli |
| KV1.3 | Agitoxin-2 | RTA-420 | Recombinant, E. coli |
| KV1.3 | Agitoxin-2-Cys-TAMRA | RTA-420-T | Recombinant, E. coli |
| KV1.3 | Agitoxin-3 | RTA-390 | Recombinant, E. coli |
| KV1.3 | HsTx1 | STH-300 | Synthetic peptide |
| KV1.3, KV1.6 | Margatoxin | STM-325 | Synthetic peptide |
| KV1.5, Kir2.3 | Carvedilol | C-180 | Synthetic |
| KV1.5, KV11.1 | Trimethylapigenin | T-145 | Synthetic |
| KV2 | Citalopram | C-195 | Synthetic |
| KV2 | Citalopram hydrobromide | C-185 | Synthetic |
| KV2.1 ,NaV1.5 | Jingzhaotoxin-III | STJ-200 | Synthetic peptide |
| KV2.1, NaV, CaV3.1, TRPA1 | ProTx-I | STP-400 | Synthetic peptide |
| KV3.4 , NaV | BDS-I | B-400 | Natural peptide |
| KV3.4 | BDS-II | B-450 | Natural peptide |
| KV4, TRPM3, TRPC5 | Rosiglitazone | R-125 | Synthetic |
| KV4 | Heteropodatoxin-2 | STH-340 | Synthetic peptide |
| KV4.1, NaV1.5 | Jingzhaotoxin-XII | STJ-100 | Synthetic peptide |
| Kv4.2, Kv4.3 ,NaV 離子通道 | Jingzhaotoxin-V | STJ-050 | Synthetic peptide |
| KV4.2, KV4.3 | Phrixotoxin-1 | P-710 | Natural peptide |
| KV4.2, KV4.3 | Phrixotoxin-2 | P-700 | Natural peptide |
| KV7 離子通道 | Linopirdine | L-155 | Synthetic |
| KV7 離子通道 | Linopirdine dihydrochloride | L-156 | Synthetic |
| KV7 離子通道 | XE991 | X-100 | Synthetic |
| KV7 離子通道 | XE991 dihydrochloride | X-101 | Synthetic |
| KV11.1 | BeKm-1 | RTB-470 | Recombinant, E. coli |
| KV11.1 | Dofetilide | D-100 | Synthetic |
| KV11.1 | E-4031 | E-500 | Synthetic |
| KV11.1 | Ergtoxin-1 | RTE-450 | Recombinant, E. coli |
| KV11.1 , NaV 離子通道 | GrTx1 | STG-250 | Synthetic peptide |
| KV11.1 channels, TTX-sensitive NaV | GsAF-I | STG-300 | Synthetic peptide |
| KV11.1 channels, TTX-sensitive NaV | GsAF-II | STG-350 | Synthetic peptide |
| KV11.1 , NaV1.3 離子通道 | Haplotoxin-2 | STT-200 | Synthetic peptide |
鈣激活鉀離子通道Blocker
| 靶點(diǎn)通道 | 品名 | 貨號 | 來源 |
| KCa，NaV | Bupivacaine hydrochloride | B-125 | Synthetic |
| KCa | Paxilline | P-450 | Natural |
| KCa1.1, KV1.2, KV1.3 | Charybdotoxin | STC-325 | Synthetic peptide |
| KCa1.1 | Iberiotoxin | STI-400 | Synthetic peptide |
| KCa1.1，特定KV1 | Kaliotoxin-1 | STK-370 | Synthetic peptide |
| KCa1.1 | Penitrem A | P-650 | Natural |
| KCa1.1 | Slotoxin | RTS-410 | Recombinant, E. coli |
| KCa1.1 | Verruculogen | V-500 | Natural |
| KCa2 | Apamin | STA-200 | Synthetic peptide |
| KCa2 | Scyllatoxin | STS-370 | Synthetic peptide |
| KCa2 | Tamapin | STT-400 | Synthetic peptide |
| KCa3 and KV1.2 | Maurotoxin | STM-340 | Synthetic peptide |
| KV1.1, KV1.2, KV1.3, KCa3.1 | OsK-1 | RTO-150 | Recombinant, E. coli |
| KCa3.1 | TRAM 34 | T-105 | Synthetic |
內(nèi)向整流型鉀離子通道Blocker
| 靶點(diǎn)通道 | 品名 | 貨號 | 來源 |
| Kir1.1 | Tertiapin-LQ | STT-220 | Synthetic modified peptide |
| Kir1.1 | Lq2 | RTL-550 | Recombinant, E. coli |
| Kir1.1, Kir3.2 | Tertiapin | STT-250 | Synthetic peptide |
| Kir1.1，KV1.1, KV1.6 | δ-Dendrotoxin | D-380 | Natural peptide |
| Kir1.1, Kir3.2 | Tertiapin-Q | STT-170 | Synthetic peptide |
| KV1.5, Kir2.3, adrenoceptors | Carvedilol | C-180 | Synthetic |
| KV4, TRPM3, TRPC5 | Rosiglitazone | R-125 | Synthetic |
帶熒光標(biāo)記的鉀離子通道Blocker
| 靶點(diǎn)通道 | 品名 | 貨號 | 熒光標(biāo)記 | 來源 |
| Kir1.1, Kir3.2 | Tertiapin-Q-ATTO-488 | STT-170-AG | ATTO Fluor-488 | Synthetic peptide |
| Kir1.1, Kir3.2 | Tertiapin-Q-ATTO-633 | STT-170-FR | ATTO Fluor -633 | Synthetic peptide |
| KV1.2 | Tityustoxin-Kα (A20C)-ATTO-594 | STT-360-AR | ATTO Fluor -594 | Synthetic peptide |
關(guān)于Alomone
Alomone是來自以色列的離子通道抗體專家，每個批次的產(chǎn)品都經(jīng)過嚴(yán)格的質(zhì)量控制測試和驗(yàn)證。 抗體產(chǎn)品會通過免疫多肽驗(yàn)證其特異性，其他藥理學(xué)試劑和重組蛋白則均通過嚴(yán)格的生物檢驗(yàn)。
優(yōu)寧維作為Alomone在中國區(qū)的授權(quán)代理商，建立了中國現(xiàn)貨庫，為廣大客戶帶去更快的物流，更好的服務(wù)。
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