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            您現(xiàn)在的位置： 首頁(yè)> 公司動(dòng)態(tài)> Imgenex公司表觀遺傳學(xué)研究工具：Dnmt與HDAC抗體
            
  
            
    
            
        
        
            
          
            
            
            Imgenex公司表觀遺傳學(xué)研究工具：Dnmt與HDAC抗體
            2011-10-5　　閱讀(4494)
            
           
            
							
				
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            Imgenex公司表觀遺傳學(xué)研究工具：Dnmt與HDAC抗體
                                    		        
                    
                                 
                    
                                    
                                                
                                                            
                                                                        
                                                                                    
            Dnmt and HDAC Antibodies for Epigenetics
                                                Cell Regulation & DNA Repair             
                                                            		                                
                                                                            
                                                		                    
                                
                                                         
                                
                                                            
                                                                        
                                                                                    
                                                                                                
                                                                                                            
            Histonedeacetylases exert transciptional control through deacetylation of core histone proteins. DNA methyltransferases regulate gene expression through cytosine methylation –changes in methylation patterns have been linked with neoplasia development. As a recognized leader and tool provider for cell regulatory pathway analysis, IMGENEX provides a comprehensive choice of highly referenced, validated antibodies specific for HDACs and Dnmts. We are continuing to build upon our leading portfolio for studying cell regulation by introduction of new products including transcription factors, ChIP Kits, signaling molecules and other key biomarkers. Utilization of our Pathway Profiling expertise and products continues to enable advanced research in Cancer, Apoptosis, Stem Cell/Developmental Biology and Immune/Inflammation Signaling Pathways.
                                                                         
                                                                        		                                            
                                                        
                                                                                                            
                                                                                                                        
                                                                                                                                    
                                                                                                                                                
                                                                                                                                                            
            Applications:
                                                                                                		                                                                    
                                                                                
                                                                                                                                                            
            •  Western Blot
                                                                                    •  IHC
                                                                                    •  ChIP
                                                                                    •  Flow Cytometry
                                                                                     
                                                                                                		                                                                    
                                                                                
                                                                                                                                                         
                                                                                
                                                                                    HDAC Antibodies                                                                    
                                                                                
                                                                                                                                                            
                                                                                                                                                                                                                                                    
                                                                                                HDAC-1                                                                                    HDAC-6                                                                                
                                                                                            
                                                                                                HDAC-2 （Ab-394）                                                                                    HDAC-7                                                                                
                                                                                            
                                                                                                HDAC-3                                                                                    HDAC-7 （Ser155）                                                                                
                                                                                            
                                                                                                HDAC-4                                                                                    HDAC-7 （Ser318）                                                                                
                                                                                            
                                                                                                HDAC-4 （Ab-632）                                                                                    HDAC-7 （Ser448）                                                                                
                                                                                            
                                                                                                HDAC-4 （Ser632）                                                                                    HDAC-8 （Ab-39）                                                                                
                                                                                            
                                                                                                HDAC-5                                                                                    HDAC-8 （Ser39）                                                                                
                                                                                            
                                                                                                HDAC-5 （Ab-498）                                                                                    HDAC-9                                                                                
                                                                                            
                                                                                                HDAC-5 （Ser498）                                                                                                                                                                     
                                                                                                                                                                            
                                                                                                		                                                                    
                                                                                
                                                                                                                                                         
                                                                                
                                                                                    Dnmt Antibodies                                                                    
                                                                                
                                                                                                                                                            
                                                                                                                                                                                                                                                    
                                                                                                Dnmt1                                                                                    Dnmt3a                                                                                
                                                                                            
                                                                                                Dnmt2                                                                                    Dnmt3b                                                                                
                                                                                                                                                                            
                                                                                                		                                                                    
                                                                                
                                                                                                                                                         
                                                                                
                                                                                                                                                            
            Related Pathways
                                                                                                		                                                                    
                                                                                
                                                                                                                                                            
                                                                                                                                                                        
                                                                                                Transcription Factors                                                                                
                                                                                            
                                                                                                Apoptosis Detection Kits/pSIVA                                                                                
                                                                                            
                                                                                                NF-kB Pathway                                                                                
                                                                                                                                                                            
                                                                                                		                                                                    
                                                                                                                                                    
                                                                                    		                                                                                                                                                                                     
                                                                                                                                                
                                                                                                                                                            
                                                                                                                                                                        
                                                                                                                                                                                    
                                                                                                                                                                                                
                                                                                                            Dnmt3a, IMG-268A                                                                                            
                                                                                                        
                                                                                                                                                                                                        
                                                                                                        
                                                                                                                                                                                                            
            Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium （OE）. DNMT3a （red） is co-expressed with neuron-specific tubulin （green） throughout the development of the olfactory epithelium, using IMG-268A. （Data courtesy of A. Jane Roskams, University of British Columbia）.
                                                                                                                        		                                                                                            
                                                                                                                                                                                                    
                                                                                                            		                                                                                
                                                                                                                                                                            
                                                                                                		                                                                    
                                                                                
                                                                                                                                                         
                                                                                
                                                                                                                                                            
                                                                                                                                                                        
                                                                                                                                                                                    
                                                                                                                                                                                                
                                                                                                            HDAC-7 （Ser155）, IMG-612                                                                                            
                                                                                                        
                                                                                                                                                                                                        
                                                                                                        
                                                                                                                                                                                                            
            Western blot analysis of phosphorylated HDAC-7 in （A） recombinant fusion protein containin a phosphorylated serine at position 155 and （B） fusion protein containing an unphosphorylated serine at position 155, using IMG-612 at 0.1 ug/ml.
                                                                                                                        		                                                                                            
                                                                                                                                                                                                    
                                                                                                            		                                                                                
                                                                                                                                                                            
                                                                                                		                                                                    
                                                                                                                                                    
                                                                                    		                                                        
                                                                                                                            
                                                                        		                                            
                                                                                                    
                                                            		                                
                                                                            
                                                		                    
                                                    
                        
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