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            BioPorto ABS 033-10B-005 說(shuō)明書

            2017-6-28  閱讀(3206)

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            上海起發(fā)專業(yè)代理并分銷BioPorto糖尿病、肥胖癥等代謝疾病相關(guān)的單克隆抗體。蛋白質(zhì)/多肽類激素通常是產(chǎn)生于特定刺激后分泌到循環(huán)系統(tǒng)中的激素原,一旦分泌,大多數(shù)的肽激素在血液循環(huán)自由存在。在穿越血液循環(huán)的同時(shí),在靶細(xì)胞表面遇到受體,并與特定的內(nèi)分泌細(xì)胞上的細(xì)胞表面受體結(jié)合。內(nèi)分泌細(xì)胞合成,儲(chǔ)存和分泌蛋白質(zhì)/多肽激素,并再次激活各種信號(hào)轉(zhuǎn)導(dǎo)系統(tǒng),內(nèi)分泌的紊亂會(huì)引起多種代謝疾病。

            糖尿病相關(guān)

            胰高血糖素樣肽-1(GLP-1) 存在多種剪切體,包括GLP-1 Extended form、GLP-1 Active form及GLP-1 Metabolite等。BioPorto專業(yè)提供針對(duì)各種形式GLP-1的單克隆抗體,用于GLP-1糖尿病治療的研究及檢測(cè),為早期研發(fā)階段、臨床階段I和/或在zui終治療產(chǎn)品的生產(chǎn)和質(zhì)量控制過(guò)程提供可靠依據(jù)。

            Bioporto傳染性疾病研究相關(guān)單克隆抗體 - 西寶生物專業(yè)代理

            圖1 不同形式的GLP-1 (Glucagon-likepeptide1)示意圖

            提供胰高血糖素樣肽-2(GLP-2)、胰多肽(PP)、Exendin-4、胰高血糖素(Glucagon)等糖尿病研究相關(guān)單克隆抗體:

            貨號(hào)

            產(chǎn)品名稱

            規(guī)格

            宿主

            應(yīng)用

            ABS 033-04-02

            Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

            200µl

            Mouse

            ELISA, IHC

            ABS 033-04-1

            Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

            1ml

            Mouse

            ELISA, IHC

            ABS 033-10-02

            Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

            200µl

            Mouse

            ELISA, WB

            ABS 033-10-1

            Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

            1ml

            Mouse

            ELISA, WB

            ABS 033-10B-005

            Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

            50µl

            Mouse

            ELISA

            ABS 044-49-02

            Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

            200µl

            Mouse

            ELISA, WB

            ABS 044-49-1

            Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

            1ml

            Mouse

            ELISA, WB

            ABS 044-53-02

            Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

            200µl

            Mouse

            ELISA, WB

            ABS 044-53-1

            Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

            1ml

            Mouse

            ELISA, WB

            ABS 046-03-02

            Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)

            200µl

            Mouse

            ELISA, WB

            ABS 046-03-1

            Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)

            1ml

            Mouse

            ELISA, WB

            ABS 046-03B-005

            Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)

            50µl

            Mouse

            ELISA

            HYB 011-05-02

            Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)

            200µl

            Mouse

            ELISA, WB

            HYB 011-05-1

            Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)

            1ml

            Mouse

            ELISA, WB

            HYB 147-06-02

            Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)

            200µl

            Mouse

            ELISA, IHC

            HYB 147-06-1

            Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)

            1ml

            Mouse

            ELISA, IHC

            HYB 147-06B-005

            Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)

            50µl

            Mouse

            ELISA

            HYB 147-08-02

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            200µl

            Mouse

            ELISA, WB

            HYB 147-08-1

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            1ml

            Mouse

            ELISA, WB

            HYB 147-08B-005

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            50µl

            Mouse

            ELISA

            HYB 147-12-02

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            200µl

            Mouse

            ELISA, WB, IHC

            HYB 147-12-1

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            1ml

            Mouse

            ELISA, WB, IHC

            HYB 147-12B-005

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            50µl

            Mouse

            ELISA

            HYB 147-13-02

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            200µl

            Mouse

            ELISA, WB

            HYB 147-13-1

            Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

            1ml

            Mouse

            ELISA, WB

            HYB 006-02-02

            Glucagon-like peptide-2 (human, GLP-2)

            200µl

            Mouse

            ELISA

            HYB 006-02-1

            Glucagon-like peptide-2 (human, GLP-2)

            1ml

            Mouse

            ELISA

            ABS 030-06-02

            Pancreatic Polypeptide (human, PP)

            200µl

            Mouse

            ELISA, WB

            ABS 030-06-1

            Pancreatic Polypeptide (human, PP)

            1ml

            Mouse

            ELISA, WB

            HYB 347-06-02

            Pancreatic PolyPeptide (PP)

            200µL

            Mouse

            ELISA

            HYB 347-06-1

            Pancreatic PolyPeptide (PP)

            1ml

            Mouse

            ELISA

            ABS 012-20-02

            Exendin-4

            200µl

            Mouse

            ELISA

            ABS 012-20-1

            Exendin-4

            1ml

            Mouse

            ELISA

            ABS 012-24-02

            Exendin-4

            200µl

            Mouse

            ELISA

            ABS 012-24-1

            Exendin-4

            1ml

            Mouse

            ELISA

            ABS 012-35-02

            Exendin-4

            200µl

            Mouse

            ELISA

            ABS 012-35-1

            Exendin-4

            1ml

            Mouse

            ELISA

            ABS 012-35B-005

            Exendin-4

            50µl

            Mouse

            ELISA

            ABS 058-08-02

            Glucagon (human, pig, rat)

            200µl

            Mouse

            ELISA

            ABS 058-08-1

            Glucagon (human, pig, rat)

            1ml

            Mouse

            ELISA

            ABS 058-08B-005

            Glucagon (human, pig, rat)

            50µl

            Mouse

            ELISA

            ABS 061-09-02

            Glucagon (human, pig, rat)

            200µl

            Mouse

            ELISA

            ABS 061-09-1

            Glucagon (human, pig, rat)

            1ml

            Mouse

            ELISA

             

            Anti-GLP-1(7-37) and GLP-1(7-36)amide (N-terminal specific)

            CAT.NO. ABS 033-10B

            DELIVERY: 1-5 DAYS

             

            Cat. No.

            ABS 033-10B

            Product name

            Anti-GLP-1(7-37) and GLP-1(7-36)amide (N-terminal specific)

            Description

            Mouse monoclonal antibody, biotinylated

            Specificity

            ABS 033-10 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity with GLP-1(9-36)amide, glucagon and human GIP. Cross-reacts 0.25% with GLP-1(1-37), approximay 6% with human GLP-2 and approximay 50% with exendin-4. ABS 033-10 cross-reacts with Liraglutide.聽

            Immunogen

            Synthetic GLP-1(7-17)聽

            Application

            ELISA

            Species reactivity (positive)

            Human

            Species reactivity (negative)

            Not determined

            Subclass

            IgG2a/k

            Gene ID

            2641

            Clone number

            10

            Epitope

            Free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.

            Content

            50 碌L, 1 mg/mL +/- 15%. See Certificate of Analysis for details.

            Purification

            Biotinylated

            Form

            Liquid

            Solvent

            0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

            Storage

            4-8ºC without exposure to light. No precautions necessary during handling.

            Target

            Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

             

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